The widening medication adherence gap

Source briefing · A concise briefing based on one linked source. It is intentionally shorter than a full FreedomWitness Evidence Engine analysis.

What the source reports

by Zachary A. Marcum The gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. Closing this gap requires more than individual behavior change; it requires system-level solutions, including coverage and funding design, pharmacist-led programs, and health information technology.

In this Perspective, Zachary Marcum argues that the gap between medication efficacy in trials and real-world effectiveness is widening, and with it the opportunity cost of medication nonadherence. He discusses why closing this…

Evidence note: At this stage FreedomWitness is presenting what this source reports. This briefing does not independently prove every underlying claim and should be read together with the original material.

Source & verification

Primary source: PLOS Medicine · September 4, 2026

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