Sex differences in trajectories to cardio-renal and mental health outcomes following the onset of type 2 diabetes: An observational cohort study using multi-state analysis in the UK Clinical Practice Research Datalink

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What the source reports

by Fabiola Eto, Miriam Samuel, Daniel Stow, Rafael Henkin, Alisha Angdembe, Michael R. Barnes, Sarah Finer, Rohini Mathur Background Type 2 diabetes (T2D) presents a significant global health challenge, and its prevalence is expected to rise.

T2D is associated with diverse complications, including cardiovascular diseases (CVD), end-stage renal disease (ESRD), and mental health disorders like depression and anxiety. Previous research has demonstrated sex differences in the metabolic risk profile, clinical characteristics, and care related to T2D and its complications, including mental health…

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Source & verification

Primary source: PLOS Medicine · August 25, 2026

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