Protein mediators of chronic kidney disease in Type 2 diabetes: A mendelian randomization study

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What the source reports

by Kevin Y. H. Liang, Thomas M. Zheng, Dandan Tan, Takayoshi Sasako, Yann Ilboudo, Yiheng Chen, Guillaume Butler-Laporte, Satoshi Yoshiji, J.

Brent Richards Background Chronic kidney disease (CKD) occurs in 20–50% of the people living with Type 2 diabetes (T2D) and is the leading cause of kidney failure worldwide. The cause of CKD is not fully understood, and few interventions prevent CKD in individuals living with diabetes. Here, we use large-scale proteomics data to identify circulating proteins that mediate the relationship between…

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Source & verification

Primary source: PLOS Medicine · September 11, 2026

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