Multimodal protective and susceptibility clusters in paediatric atopic dermatitis: A machine learning-based, data-driven observational study

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What the source reports

by Damir Zhakparov, Nonhlanhla Lunjani, Marco Schmid, Kathleen Moriarty, Damian Roquero, Anita Dreher, Jeannette I. Heldstab-Kast, Kari C. Nadeau, Cezmi Akdis, Michael Levin, Carol Hlela, Milena Sokolowska, Liam O’Mahony, Katja Baerenfaller Background Atopic dermatitis (AD) is a chronic inflammatory skin disease that typically develops in early childhood.

Differences in AD prevalence and allergy sensitisation patterns have been observed in African populations, including the AmaXhosa population in South Africa, suggesting alternative pathogenic and immune mechanisms underlying AD. Differences in AD prevalence have also…

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Source & verification

Primary source: PLOS Medicine · September 8, 2026

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